Neopterin and Cellular Immune Activation in Active Gynaecological Cancer: Significant Correlation Between Neopterin and Circulating Number of HLA-DR Expressing Lymphocytes

Neopterin and Cellular Immune Activation in Active Gynaecological Cancer: Significant Correlation Between Neopterin and Circulating Number of HLA-DR Expressing Lymphocytes

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Urine concentrations of neopterin, a marker for the activation of cellular immunity, were determined concomitantly with a large panel of hematological and immunological variables on 24 women with gynaecological cancers (12 uterine cervix, 5 endometrium, 7 ovary).There were 14 women investigated at first diagnosis of carcinoma, and 10 women chiggate.com were studied during follow-up (evidence of disease, only palliative treatment during the preceding three months).A statistically significant correlation was found between neopterin concentrations and number of circulating non-B lymphocytes expressing HLA-DR antigen.Neopterin concentrations, numbers of HLA-DR positive cells, and numbers of circulating leukocytes were significantly higher in women studied during follow-up, when compared with women freshly diagnosed.In click here contrast.

numbers of CD4 +, CD3 +, CD19 + lymphocytes and of total lymphocytes in peripheral blood were significantly lower in women studied during follow-up.The results suggest that high neopterin levels in tumor patients indicate activation of early steps of cellular immune mechanisms.